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安全信息

SML0847

Sigma-Aldrich

苯扎托品 甲磺酸盐

≥98% (HPLC)

别名:

苯托品 甲磺酸盐

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About This Item

经验公式（希尔记法）:
C21H25NO · CH3SO3H
CAS号:
132-17-2
分子量:
403.53
EC 号:
205-048-8
MDL编号:
MFCD00074784
UNSPSC代码:
12352200
PubChem化学物质编号:
329825609
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4

InChI

1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;

InChI key

CPFJLLXFNPCTDW-BWSPSPBFSA-N

基因信息

human ... CHRM1(1128)

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一般描述

Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.

应用

Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection. It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).

生化/生理作用

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.
Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H302,H311 + H331

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

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分析证书(COA)

Lot/Batch Number
0000163007
0000158505
0000135982

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Target identification and mode of action of four chemically divergent drugs against ebolavirus infection
Ren J, et al.
Journal of medicinal chemistry, 61(3), 724-733 (2018)
Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)?A Potential Target to Treat Metabolic Disorders
Javed K, et al.
Clinical Therapeutics, 19(11), 3597-3597 (2018)
New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate
Cui J, et al.
Oncotarget, 8(1), 1007-1007 (2017)
Björn Neumann et al.
Cell stem cell, 25(4), 473-485 (2019-10-05)
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show that the differentiation potential of adult
Lisa M Johansen et al.
Science translational medicine, 7(290), 290ra89-290ra89 (2015-06-05)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential

商品

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

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