推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4
InChI
1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;
InChI key
CPFJLLXFNPCTDW-BWSPSPBFSA-N
基因信息
human ... CHRM1(1128)
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一般描述
Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.
应用
Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection. It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).
生化/生理作用
Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.
Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Target identification and mode of action of four chemically divergent drugs against ebolavirus infection
Ren J, et al.
Journal of medicinal chemistry, 61(3), 724-733 (2018)
Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)?A Potential Target to Treat Metabolic Disorders
Javed K, et al.
Clinical Therapeutics, 19(11), 3597-3597 (2018)
New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate
Cui J, et al.
Oncotarget, 8(1), 1007-1007 (2017)
Björn Neumann et al.
Cell stem cell, 25(4), 473-485 (2019-10-05)
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show that the differentiation potential of adult
Lisa M Johansen et al.
Science translational medicine, 7(290), 290ra89-290ra89 (2015-06-05)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
DISCOVER Bioactive Small Molecules for Neuroscience
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