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质量水平
方案
≥96% (HPLC)
表单
film
颜色
colorless
运输
wet ice
储存温度
−20°C
SMILES字符串
N(C)(C)C(=O)[C@H]1[C@H]([C@@]2([C@@](Oc5c2c(cc(c5)OC)OC)([C@@H]1c4ccccc4)c3ccc(cc3)OC)O)O
InChI
1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
InChI key
DAPAQENNNINUPW-IDAMAFBJSA-N
一般描述
已知楝酰胺来自于四氢苯并呋喃，并且也是树兰属植物的一种活性化合物。
应用
楝酰胺已被用作抗癌药用于治疗肠病毒71型神经发病机制并对抑制素的作用进行了研究。
生化/生理作用
楝酰胺与成骨细胞分化相关。在类风湿关节炎中，楝酰胺可能通过阻止参与其中的细胞因子的表达而抑制炎症。
楝酰胺是一种从树兰属中分离的有效抗癌剂。楝酰胺可抑制蛋白的合成而不影响DNA或RNA合成。最近的研究表明，楝酰胺可与禁止素（PHB）1和2结合，阻止PHB与CRaf之间的相互作用并抑制CRaf的活化，进而抑制CRaf-MEK-ERK信号转导。此外，楝酰胺也是一种抑制NF-κB和NF-AT活化的免疫抑制剂。
楝酰胺是一种有效的抗癌剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Bernd Baumann et al.
The Journal of biological chemistry, 277(47), 44791-44800 (2002-09-19)
Crude extracts from different Aglaia species are used as anti-inflammatory remedies in the traditional medicine of several countries from Southeast Asia. Because NF-kappaB transcription factors represent key regulators of genes involved in immune and inflammatory responses, we supposed that the
F I Bohnenstengel et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 54(12), 1075-1083 (2000-02-24)
Thirteen naturally occurring 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type as well as one naturally occurring aglain congener all of them isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis) collected in Vietnam were studied for their antiproliferative
Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-?B Signaling.
Li A, et al.
Molecular Cell, 38(11), 941-941 (2015)
Baudouin Gerard et al.
Journal of the American Chemical Society, 128(24), 7754-7755 (2006-06-15)
Enantioselective syntheses of methyl rocaglate and the related natural products rocaglamide and rocaglaol are outlined. The approach involves enantioselective [3 + 2] photocycloaddition promoted by chiral Brønsted acids (TADDOLs) to afford an aglain precursor followed by a ketol shift/reduction sequence
Soyoung Kim et al.
Anti-cancer agents in medicinal chemistry, 6(4), 319-345 (2006-07-18)
During the past few years, a group of cyclopenta[b]benzofurans from the plant genus Aglaia has received broad scientific attention as interesting natural product lead compounds with potential anticancer and insecticidal activities. Since the first cyclopenta[b]benzofuran derivative, rocaglamide, from Aglaia elliptifolia
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The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.
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