推荐产品
生物来源
plant (Thapsia garganica)
质量水平
检测方案
≥98% (HPLC)
形式
solid film
溶解性
acetonitrile: soluble 9.80-10.20 mg/mL
DMSO: soluble
ethanol: soluble
储存温度
−20°C
SMILES字符串
[H][C@@]12C([C@H](OC([C@]3(O)C)=O)[C@]3(O)[C@@H](OC(CCC)=O)C[C@]2(C)OC(C)=O)=C(C)[C@H](OC(/C(C)=C(C)/[H])=O)[C@H]1OC(CCCCCCC)=O
InChI
1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChI key
IXFPJGBNCFXKPI-FSIHEZPISA-N
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一般描述
毒胡萝卜素(Thapsigargin)是一种愈创木内酯倍半萜内酯,是一种广泛使用的肌质网/内质网Ca2+ ATP酶(SERCA)抑制剂。它可激活内质网(ER)应激和未折叠蛋白质应答。 毒胡萝卜素是一种天然植化素,存在于地中海植物毒胡萝卜(Thapsia garganica)的根和果实中。毒胡萝卜素可使停滞翻译恢复并诱导冠状病毒(CoV)感染细胞内的代谢途径发生全蛋白质组变化。
应用
毒胡萝卜素已用作内质网(ER)应激诱导因子:
- 研究其对肝癌细胞中环化酶相关蛋白质2(CAP2)表达的影响
- 使用ARPE-19细胞(人视网膜色素上皮细胞)进行细胞活力测试
- 研究其对原发性肝细胞磷脂2(LCN2)糖基化的影响
- 研究细胞内质网 (ER) 钙消耗的后果
- 研究其对大鼠支持细胞中金属蛋白酶组织抑制剂-1 (TIMP-1) mRNA表达的影响
生化/生理作用
毒胡萝卜素是强有效的可穿透细胞的IP3-依赖型细胞内钙释放器。 它阻断由血管抑制素和内皮抑素诱导的细胞内Ca2+的瞬时增加。它也通过破坏细胞内游离Ca2+水平诱导细胞凋亡;并掺入进化学治疗前药的配方中。
警示用语:
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases
Trends in Pharmacological Sciences (1998)
Thapsigargin: key to new host-directed coronavirus antivirals?
Trends in Pharmacological Sciences (2022)
Thapsigargin-From Traditional Medicine to Anticancer Drug
International Journal of Molecular Sciences (2020)
Biology of reproduction, 62(4), 1040-1046 (2000-03-22)
In the testis, FSH has been shown to induce the expression and secretion of tissue inhibitor of metalloproteinases-1 (TIMP-1) from Sertoli cells in vitro. This study was performed to elucidate further the cellular origin of testicular TIMP-1 and its expression
Human molecular genetics, 19(21), 4160-4175 (2010-08-12)
Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the mechanism by which these mutants cause motor neuron degeneration is not known. We report a novel ALS truncation mutant (R495X) that leads
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