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Merck
CN
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文件

SML0445

Sigma-Aldrich

克立马丁 富马酸盐

≥98% (HPLC)

别名:

(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine

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About This Item

经验公式（希尔记法）:
C21H26ClNO · C4H4O4
CAS号:
14976-57-9
分子量:
459.96
EC 号:
239-055-2
MDL编号:
MFCD00137486
UNSPSC代码:
12352200
PubChem化学物质编号:
329824727
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +15 to +25°, c = 1 in methanol

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution; warmed)

储存温度

room temp

SMILES字符串

OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChI key

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

基因信息

human ... HRH1(3269)

一般描述

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

应用

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

生化/生理作用

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Annemarie B Lüchinger et al.
The American journal of the medical sciences, 341(3), 240-242 (2011-01-15)
Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests
Wafaa S Hassan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 69(1), 245-255 (2007-06-08)
Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the determination of three histamine H1-antagonists drugs, e.g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations. The first method depend
Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial
Green AJ, et al.
Lancet, 390(10111), 2481-2489 (2017)
Effectiveness of clemastine fumarate for treatment of rhinorrhea and sneezing associated with the common cold
Turner RB, et al.
Clinical Infectious Diseases, 25(4), 824-830 (1997)
Vanessa E Hogan et al.
Annals of the rheumatic diseases, 71(11), 1888-1894 (2012-06-28)
Personalised healthcare is contingent on the identification of biomarkers that represent disease relevant pathways and predict drug response. The authors aimed to develop a gene expression signature in synovial tissue that could enrich clinical response of rheumatoid arthritis (RA) patients
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