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质量水平
方案
≥98% (HPLC)
表单
powder
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
white to beige
溶解性
DMSO: 5 mg/mL (clear solution; warmed)
储存温度
room temp
SMILES字符串
CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChI key
UBRKDAVQCKZSPO-UHFFFAOYSA-N
应用
AF-DX 116 用作 M2 毒蕈碱受体（M2AChR）选择性拮抗剂，以研究 M2AChR 对年轻糖尿病大鼠齿状回基底和碳水化合物刺激长期增强（DG-LTP）的调节和海马细胞前神经生长因子（proNGF）分泌的影响。
生化/生理作用
AF-DX 116 可在反复冷应激诱导的低血压大鼠模型中升高血压和心率。因此，它可以治疗与迷走神经症型自主神经功能障碍相关的低血压。
AF-DX 116是一种选择性M2毒蕈碱乙酰胆碱受体拮抗剂。
特点和优势
该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Marti et al.
Journal of veterinary pharmacology and therapeutics, 28(6), 565-574 (2005-12-14)
The goal of this study was to investigate the effect of bethanechol (BeCh) on contractility patterns of smooth muscle preparations of equine duodenum descendens, jejunum, caecum and pelvic flexure in vitro. Concentration-response relationships were developed for BeCh using in vitro
T Hata et al.
Japanese journal of pharmacology, 85(3), 313-321 (2001-04-28)
Rats exposed to SART (specific alternation of rhythm in temperature) stress, which are ideal animal models for vagotonia-type dysautonomia, show various changes in cardiac and circulatory systems. In this study, attention was directed to cholinergic function in the SART-stressed rat
Takio Kitazawa et al.
European journal of pharmacology, 554(2-3), 212-222 (2006-11-23)
Functional roles of muscarinic acetylcholine receptors in the regulation of mouse stomach motility were examined using mice genetically lacking muscarinic M(2) receptor and/or M(3) receptor and their corresponding wild-type (WT) mice. Single application of carbachol (1 nM-30 microM) produced concentration-dependent
Marzia Soligo et al.
Scientific reports, 7(1), 9077-9077 (2017-08-24)
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the
Y Doi et al.
European journal of pharmacology, 505(1-3), 31-35 (2004-11-24)
This study characterized the functional effects of a novel gastroprokinetic agent, N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1, 3-thiazole-4-carboxyamide monohydrochloride trihydrate (Z338), on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes using the two-electrode voltage clamp method. Z-338 did not produce by itself
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