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Merck
CN

SML0435

AF-DX 116

≥98% (HPLC)

别名:

11-[[2-[(二乙胺基)甲基]-1-哌啶基]乙酰基]-5,1 1-二氢-6-吡啶并[2,3-b][1,4]苯二氮卓-6-酮, Otenzepad

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关于此项目

经验公式(希尔记法):
C24H31N5O2
化学文摘社编号:
分子量:
421.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI

1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)

SMILES string

CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24

InChI key

UBRKDAVQCKZSPO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution; warmed)

storage temp.

room temp

Quality Level

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Application

AF-DX 116 用作 M2 毒蕈碱受体(M2AChR)选择性拮抗剂,以研究 M2AChR 对年轻糖尿病大鼠齿状回基底和碳水化合物刺激长期增强(DG-LTP)的调节和海马细胞前神经生长因子(proNGF)分泌的影响。

Biochem/physiol Actions

AF-DX 116 可在反复冷应激诱导的低血压大鼠模型中升高血压和心率。因此,它可以治疗与迷走神经症型自主神经功能障碍相关的低血压。
AF-DX 116是一种选择性M2毒蕈碱乙酰胆碱受体拮抗剂。

Features and Benefits

该化合物在受体分类和信号转导手册的 乙酰胆碱受体(毒蕈碱) 页面上有详细描述。想要浏览手册的其他页面, 请单击此处

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Julia B R Pfeiffer et al.
American journal of veterinary research, 68(3), 313-322 (2007-03-03)
To describe the in vitro effects of bethanechol on contractility of smooth muscle preparations from the small intestines of healthy cows and define the muscarinic receptor subtypes involved in mediating contraction. Tissue samples from the duodenum and jejunum collected immediately
T Hata et al.
Japanese journal of pharmacology, 85(3), 313-321 (2001-04-28)
Rats exposed to SART (specific alternation of rhythm in temperature) stress, which are ideal animal models for vagotonia-type dysautonomia, show various changes in cardiac and circulatory systems. In this study, attention was directed to cholinergic function in the SART-stressed rat
Marzia Soligo et al.
Scientific reports, 7(1), 9077-9077 (2017-08-24)
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the
Takio Kitazawa et al.
European journal of pharmacology, 554(2-3), 212-222 (2006-11-23)
Functional roles of muscarinic acetylcholine receptors in the regulation of mouse stomach motility were examined using mice genetically lacking muscarinic M(2) receptor and/or M(3) receptor and their corresponding wild-type (WT) mice. Single application of carbachol (1 nM-30 microM) produced concentration-dependent
Y Doi et al.
European journal of pharmacology, 505(1-3), 31-35 (2004-11-24)
This study characterized the functional effects of a novel gastroprokinetic agent, N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1, 3-thiazole-4-carboxyamide monohydrochloride trihydrate (Z338), on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes using the two-electrode voltage clamp method. Z-338 did not produce by itself

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