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SML0346

Sigma-Aldrich

Alosetron hydrochloride

≥98% (HPLC)

别名:

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

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About This Item

经验公式（希尔记法）:
C17H18N4O·HCl
CAS号:
122852-69-1
分子量:
330.81
MDL编号:
MFCD09028027
UNSPSC代码:
12352200
PubChem化学物质编号:
329825350
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: ≥5 mg/mL at warmed

储存温度

2-8°C

SMILES字符串

CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl

InChI

1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H

InChI key

FNYQZOVOVDSGJH-UHFFFAOYSA-N

基因信息

human ... HTR3A(3359)

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相关类别

生化/生理作用

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.
Alosetron is a potent and highly selective antagonist.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H319,H412

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000427432
0000427432
0000141193
0000040422
0000040423

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Roja Rahimi et al.
Clinical therapeutics, 30(5), 884-901 (2008-06-17)
Stimulated 5-hydroxytryptamine-3 (5-HT(3)) receptors promote intestinal motility, secretion, and sensation, effects that are related to the known pathophysiology of irritable bowel syndrome (IBS). A previous meta-analysis of 6 randomized controlled trials of the 5-HT(3)-receptor antagonist alosetron found that this agent
Lin Chang et al.
The American journal of gastroenterology, 105(4), 866-875 (2010-03-04)
Alosetron is a potent, selective 5-HT(3) receptor antagonist prescribed for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) under a risk management plan (RMP). The RMP was implemented following cases of ischemic colitis (IC) and complications of constipation (CoC) associated
Eric Shah et al.
The American journal of medicine, 125(4), 381-393 (2012-03-27)
Current treatment options for irritable bowel syndrome are limited and often poorly studied. A select few drugs have been studied in irritable bowel syndrome, and the number needed to treat is frequently used to assess the relative efficacy of these
Andrea Fantuzzi et al.
Analytical chemistry, 82(24), 10222-10227 (2010-11-26)
This paper is the first report of a P450-electrode in a microfluidic format. A 30 μL microfluidic cell was made in poly(methyl methacrylate) containing the inlet, outlet, and reaction chamber with two electrode strips, one of which contains the human
James H Lewis
Drug safety, 34(7), 545-565 (2011-06-15)
Ischaemic colitis (IC) is the most common form of ischaemic injury to the gastrointestinal (GI) tract. IC typically presents with the sudden onset of lower abdominal pain, cramping and rectal bleeding, and is usually self-limited with low morbidity, although it
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