SML0329
Carcinine 二盐酸盐
≥98% (HPLC)
别名:
β-Alanylhistamine dihydrochloride, 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride, Alistin, Beta-Alanylhistamine dihydrochloride
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C8H14N4O · 2HCl
CAS号:
分子量:
255.14
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
一般描述
Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues.
应用
Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration.
生化/生理作用
Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Pei Zhou et al.
Brain, behavior, and immunity, 76, 61-73 (2018-11-09)
The activation of microglial cells is presumed to play a key role in the pathogenesis of Parkinson's disease (PD). The activity of microglia is regulated by the histamine-4 receptor (H4R), thus providing a novel target that may prevent the progression
Lea D Marchette et al.
Investigative ophthalmology & visual science, 53(7), 3572-3583 (2012-05-12)
Oxidative stress induces retinal damage and contributes to vision loss in progressive retinopathies. Carcinine (β-alanyl-histamine) is a natural imidazole-containing peptide derivative with antioxidant activity. It is predicted to scavenge 4-hydroxynonenal (4-HNE), a toxic product of lipid oxidation. The aim of
商品
We offers many products related to histamine receptors for your research needs.
我们提供多种与组胺受体相关的产品，以满足您的各类研究需求。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门