SML0269
尼替西农
≥95% (HPLC), 4-Hydroxyphenylpyruvate oxidase inhibitor, powder
别名:
2-(2-硝基-4-三氟甲基苯甲酰基)-1,3-环己二酮, 2-[2-硝基-4-（三氟甲基）苯甲酰基] 环己烷-1,3-二酮, NTBC, SC 0735, 尼替松
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关于此项目
经验公式（希尔记法）:
C14H10F3NO5
化学文摘社编号:
分子量:
329.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
尼替西农, ≥95% (HPLC)
SMILES string
[O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
InChI key
OUBCNLGXQFSTLU-UHFFFAOYSA-N
InChI
1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
assay
≥95% (HPLC)
form
powder
color
white to brown
solubility
DMSO: ≥5 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... HPD(3242)
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Application
尼替西农已经被用于：
- 诱导肝损伤
- 治疗 肩突硬蜱 细胞，抑制羟苯丙酮酸双加氧酶
- 在补充水中的活性以阻止有毒代谢产物在人肝细胞移植小鼠中的蓄积，
- 以研究其对细菌性脓疱素产生的影响。
Biochem/physiol Actions
尼替西农是4-羟苯基丙酮酸氧化酶（双加氧酶）的竞争性和可逆抑制剂。
尼替西农是一种竞品抑制剂，可逆地抑制4-羟苯基丙酮酸氧化酶（双加氧酶）。尼替西农用于治疗1型遗传性酪氨酸血症，可阻止酪氨酸降解为有害物质。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Corinne de Laet et al.
Orphanet journal of rare diseases, 8, 8-8 (2013-01-15)
The management of tyrosinaemia type 1 (HT1, fumarylacetoacetase deficiency) has been revolutionised by the introduction of nitisinone but dietary treatment remains essential and the management is not easy. In this review detailed recommendations for the management are made based on
Methods to inhibit bacterial pyomelanin production and determine the corresponding increase in sensitivity to oxidative stress
Ketelboeter LM and Bardy SL
Journal of Visualized Experiments, (102), e53105-e53105 (2015)
Johannes Sander et al.
Clinica chimica acta; international journal of clinical chemistry, 412(1-2), 134-138 (2010-10-05)
Quantification of nitisinone, 2-(nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione (NTBC) has been repeatedly described. Nevertheless monitoring of NTBC has not yet become part of routine therapy surveillance in tyrosinaemia type I (OMIM 276700). We developed a blood spot test to facilitate collection and transport of
Immunization with AgTRIO, a protein in Anopheles saliva, contributes to protection against Plasmodium infection in mice
Dragovic SM, et al.
Cell host & microbe, 23(4), 523-535 (2018)
Saikat Santra et al.
Expert opinion on pharmacotherapy, 9(7), 1229-1236 (2008-04-22)
Hereditary tyrosinaemia type 1 is a rare inherited metabolic condition, which leads to a fatal multisystemic disease in childhood. Since 1992, nitisinone - a compound developed from work on triketone herbicides - has become an effective pharmacological treatment by inhibiting
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