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质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to brown
溶解性
DMSO: ≥5 mg/mL
储存温度
−20°C
SMILES字符串
[O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
InChI
1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChI key
OUBCNLGXQFSTLU-UHFFFAOYSA-N
基因信息
human ... HPD(3242)
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应用
尼替西农已经被用于：
- 诱导肝损伤
- 治疗 肩突硬蜱 细胞，抑制羟苯丙酮酸双加氧酶
- 在补充水中的活性以阻止有毒代谢产物在人肝细胞移植小鼠中的蓄积，
- 以研究其对细菌性脓疱素产生的影响。
生化/生理作用
尼替西农是4-羟苯基丙酮酸氧化酶（双加氧酶）的竞争性和可逆抑制剂。
尼替西农是一种竞品抑制剂，可逆地抑制4-羟苯基丙酮酸氧化酶（双加氧酶）。尼替西农用于治疗1型遗传性酪氨酸血症，可阻止酪氨酸降解为有害物质。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Eva Thimm et al.
Molecular genetics and metabolism, 102(2), 122-125 (2010-11-30)
Psychomotor impairment has been described in hypertyrosinemia types II and III (HT III). Only recently cognitive deficits have also been reported in hypertyrosinemia type I (HT I). The pathogenic mechanisms responsible are unknown. Since implementation of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC, Nitisinone (Swedish
Immunization with AgTRIO, a protein in Anopheles saliva, contributes to protection against Plasmodium infection in mice
Dragovic SM, et al.
Cell host & microbe, 23(4), 523-535 (2018)
Saikat Santra et al.
Expert opinion on pharmacotherapy, 9(7), 1229-1236 (2008-04-22)
Hereditary tyrosinaemia type 1 is a rare inherited metabolic condition, which leads to a fatal multisystemic disease in childhood. Since 1992, nitisinone - a compound developed from work on triketone herbicides - has become an effective pharmacological treatment by inhibiting
Methods to inhibit bacterial pyomelanin production and determine the corresponding increase in sensitivity to oxidative stress
Ketelboeter LM and Bardy SL
Journal of Visualized Experiments, (102), e53105-e53105 (2015)
Johannes Sander et al.
Clinica chimica acta; international journal of clinical chemistry, 412(1-2), 134-138 (2010-10-05)
Quantification of nitisinone, 2-(nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione (NTBC) has been repeatedly described. Nevertheless monitoring of NTBC has not yet become part of routine therapy surveillance in tyrosinaemia type I (OMIM 276700). We developed a blood spot test to facilitate collection and transport of
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