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别名:
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride
经验公式（希尔记法）:
C14H14N2O · 2HCl
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
green-yellow
溶解性
DMSO, heptane and xylene: ≥21 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
InChI
1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H
InChI key
XJNICPXVRPOSSO-UHFFFAOYSA-N
应用
M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.
生化/生理作用
M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.
特点和优势
This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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我们公司可提供多种组胺合成和代谢相关的产品，满足您的各类研究需求。
Our company offers many products related to histamine synthesis and metabolism for your research needs.
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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