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生物来源
rabbit
质量水平
抗体产品类型
primary antibodies
克隆
monoclonal
形式
liquid
种属反应性
rat, mouse, human
浓度
0.17 mg/mL
技术
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... AIFM1(9131)
一般描述
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
免疫原
A synthesized peptide derived from human AIF.
外形
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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