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重组
expressed in HEK 293 cells
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
RM223, monoclonal
recombinant monoclonal
表单
buffered aqueous glycerol solution
种属反应性
mouse
浓度
~1 mg/mL
技术
ELISA: 0.01 μg/mL
immunoblotting: 0.5-2 μg/mL (non-reduced only)
immunocytochemistry: 0.5-2 μg/mL
immunohistochemistry: 0.5-2 μg/mL
同位素/亚型
IgG
NCBI登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
一般描述
IgG2c codes for Igh-1b. In mice, IgG2a and IgG2c are arranged in tandem on identical chromosome as two visible loci.
特异性
This antibody reacts to the Fc region of mouse IgG2c. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.
免疫原
Purified mouse IgG2c whole molecule
生化/生理作用
Mouse IgG2c generate several unique non-bonded interactions between the BC, DE and FG loops than mIgG2b. It connects to FcγRIV (Fc γ receptor IV) with a high affinity in the complex-type glycoform. In mice, IgG2c has unique immune profiles like, response, immune-decoration, because of their difference in protein sequence.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
Daniel JF, et al.
PLoS ONE, 13(2), e0192123-e0192123 (2018)
Possible allelic structure of IgG2a and IgG2c in mice.
Zhang Z, et al.
Molecular Immunology, 50(3), 169-171 (2012)
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