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生物来源
rabbit
质量水平
重组
expressed in proprietary host
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
SP228, monoclonal
种属反应性
human (tested)
技术
flow cytometry: 1:100
immunohistochemistry: 1:100
同位素/亚型
IgG
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... HLA-DPA1(3113)
相关类别
一般描述
HLA-DP is an antigen receptor and one of the MHC class II proteins. HLA-DP is a heterodimer of an alpha and a beta chain. Both chains are type I transmembrane proteins with short cytoplasmic domains. It is expressed on antigen-presenting cells and a variety of other cell types, and is also expressed by various tumors such as melanoma, gastric carcinoma, breast carcinoma, ovarian carcinoma, and lymphoma.
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) is a class II heterodimer comprising of a polymorphic β and an oligomorphic α chain. It is encoded by the gene mapped to human chromosome 6p21.33. HLA-DPA1 is generally expressed on a subset of Kupffer cells and resident macrophages in liver.
免疫原
Synthetic peptide derived from human HLA-DP alpha1 protein.
应用
Anti-HLA-DP alpha 1 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生化/生理作用
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) alloreactivity is highly relevant in clinical transplantation. It plays an essential role in the presentation of viral antigens to CD4+ T helper (Th) lymphocytes. Studies have suggested that SNP (single nucleotide polymorphisms) of HLA-DP can result in chronic hepatitis B virus (HBV) infection.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGF?1/ERK/NF-?B axis.
Wang Y, et al.
Biochimica et Biophysica Acta, 1860(7), 1551-1559 (2016)
HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through Interacting with Viral Mutations
Zhang Q, et al.
Journal of Virology, 02073-02073 (2013)
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Hu Z, et al.
Nature Genetics, 45(12), 1499-1499 (2013)
Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.
Lauterbach N, et al.
Molecular Immunology, 59(1), 19-29 (2014)
Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection
Su M, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 31(6), 765-769 (2014)
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