推荐产品
生物来源
rabbit
质量水平
重组
expressed in proprietary host
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
SP162, monoclonal
种属反应性
human (tested)
种属反应性（根据同源性预测）
rat, chicken, rabbit, mouse, pig, bovine, dog
技术
flow cytometry: 1:150
immunoblotting: 1:150
immunohistochemistry: 1:150
同位素/亚型
IgG
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... CD3E(916)
一般描述
CD3E (CD3e molecule) gene is mapped to human chromosome 11q23.3. This gene encodes fora subunit of T-cell regulator (TCR) protein complex. It possesses IgG (immunoglobulin G)-like extracelluar domain at the N-terminal, a transmembrane domain, a peptide bridge and an immunoreceptor tyrosine-based activation motif (ITAM) towards the cytoplasm. The protein also contains basic residue-rich sequence (BRS).
This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
免疫原
Synthetic peptide corresponding to internal region of the epsilon chain of human CD3 protein.
应用
Anti-CD3 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生化/生理作用
CD3E (CD3e molecule) gene is associated with actin cytoskeletal rearrangement, through activation of a number of signaling pathways. CD3E is essential for membrane binding of T-cell regulator (TCR) protein complex.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells
Paensuwan P, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 33(3) (2015)
SnapShot: forkhead transcription factors II
Tuteja G and Kaestner KH
Cell, 131(1), 192-192 (2007)
Ionic CD3- Lck interaction regulates the initiation of T-cell receptor signaling
Li L, et al.
Proceedings of the National Academy of Sciences of the USA, 114(29), E5891-E5899 (2017)
Xuan He et al.
Cell, 184(13), 3467-3473 (2021-06-17)
We previously reported that a single immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. To evaluate reduced doses of Ad26.COV2.S, 30 rhesus macaques were immunized once with 1 ×
The progression of CD56+ myeloid sarcoma: A case report and literature review
Wang X, et al.
Oncology Letters, 11(5), 3091-3096 (2016)
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