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一般描述
CD19 (cluster of differentiation 19) is a 95 kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells. This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ∼240 amino acids and is involved in the regulation of B cell function. The gene encoding CD19 is localized on human chromosome 16p11.2.
CD19 is expressed in B lymphocytes and B-cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors.
免疫原
Synthetic peptide corresponding to C-terminus of human CD19.
生化/生理作用
CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen. The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.
特点和优势
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外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
含少量动物源组分生物产品
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
Kochenderfer JN, et al.
Blood (2011)
The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity.
Fearon DT and Carter RH
Annual Review of Immunology, 13(1), 127-149 (1995)
Aleksandra Georgievski et al.
Cell death & disease, 13(4), 337-337 (2022-04-14)
Patient-derived xenografted (PDX) models were generated through the transplantation of primary acute lymphoblastic leukemia (ALL) cells into immunodeficient NSG mice. We observed that ALL cells from mouse bone marrow (BM) produced extracellular vesicles (EVs) with specific expression of inducible heat
Kemeng Wang et al.
Experimental hematology & oncology, 1(1), 36-36 (2012-12-06)
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for
A Pezzutto et al.
Journal of immunology (Baltimore, Md. : 1950), 138(9), 2793-2799 (1987-05-01)
The 95 Kd CD19 antigen is the broadest lineage specific surface marker for B cells: it is present on the surface of virtually all B lymphocytes, including early B progenitor cells. In this study we have evaluated the function of
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