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生物来源
mouse
质量水平
偶联物
biotin conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
S231B-34, monoclonal
形式
buffered aqueous solution
分子量
antigen predicted mol wt 200 kDa
种属反应性
human, rat
浓度
1 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG2a
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LRRK2(120892)
一般描述
Leucine rich repeat kinase 2 (LRRK2) is a large protein containing protein-protein interaction region enclosing two main domains for : central kinase and GTPase.
免疫原
Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
生化/生理作用
Mutation in the leucine rich repeat kinase 2 (LRRK2) gene causes familial Parkinson′s disease (PD) and sporadic PD. Mitochondrial dysfunction is observed as a result of LRRK2 gene variation.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
PBS pH 7.4, 50% glycerol, 0.1% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease
Neurobiology of Aging, 64, 157-e7-157-e7 (2018)
LRRK2 mediated Rab8a phosphorylation promotes lipid storage
Lipids in Health and Disease, 17(1), 34-34 (2018)
Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons
Stem Cell Reports, 9(6), 1839-1852 (2017)
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