推荐产品
生物来源
mouse
质量水平
偶联物
Peridinin-Chlorophyll-Protein Complex
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
S253-32, monoclonal
表单
buffered aqueous solution
分子量
antigen predicted mol wt >270, ~120 kDa
种属反应性
mouse, rat, human
浓度
1 mg/mL
技术
immunocytochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Notch1(18128)
一般描述
The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.
免疫原
Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1
生化/生理作用
The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
PBS pH7.4, 50% glycerol, 0.09% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Evolutionary significance of intra-genome duplications on human chromosomes.
Endo T, et al.
Gene, 205(1), 19-27 (1997)
Phospholipase Cγ1 Mediates Intima Formation Through Akt?Notch1 Signaling Independent of the Phospholipase Activity.
Jiang D, et al.
Journal of the American Heart Association, 6(7), e005537-e005537 (2017)
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment.
Ding X F, et al.
Scientific Reports, 6, 25780-25780 (2016)
Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.
Zhang C, et al.
Journal of Cellular and Molecular Medicine, 21(7), 1315-1328 (2017)
Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway
Xu J, et al.
American Journal of Physiology. Cell Physiology, 296(3), C535-C543 (2009)
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