生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous glycerol solution
分子量
antigen predicted mol wt 160 kDa
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Slc12a1(25065)
一般描述
Solute carrier family 12 member 1 (SLC12A1) is a Na+-K+-Cl- transporter and it is expressed in the thick ascending loop of kidneys in rats. The gene ID of the protein is 25065.
特异性
Detects ~160 kDa.
免疫原
AA109 to 129 of the rat sequence
生化/生理作用
Solute carrier family 12 member 1 (SLC12A1) functions in water reabsorption in the kidneys.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
PBS, 50% glycerol, and 0.09% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Kazuko Itoh et al.
Biochemical and biophysical research communications, 453(3), 356-361 (2014-09-30)
Sodium reabsorption via Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limbs has a major role for medullary osmotic gradient and subsequent water reabsorption in the collecting ducts. We investigated intrarenal localization of three isoforms of NKCC2 mRNA expressions and
Yanting Chen et al.
Frontiers in physiology, 12, 642274-642274 (2021-04-20)
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin receptor (PRR)/soluble prorenin receptor
Hyperphosphorylation of Na-K-2Cl cotransporter in thick ascending limbs of Dahl salt-sensitive rats.
Gustavo R Ares et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1464-1470 (2012-10-31)
Salt-sensitive hypertension involves a renal defect preventing the kidney from eliminating excess NaCl. The thick ascending limb of Henle loop reabsorbs ≈ 30% of filtered NaCl via the apical Na-K-2Cl cotransporter (NKCC2). Higher NKCC2 activity and Cl reabsorption have been
Aurélie Edwards et al.
American journal of physiology. Renal physiology, 307(2), F137-F146 (2014-05-23)
This study aims to understand the extent to which modulation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2.
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