生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
分子量
antigen predicted mol wt 27 kDa
种属反应性
rat, human, mouse
浓度
1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HSPB2(3316)
一般描述
Heat shock protein family B, member 2 (HSPB2) is also called as myotonic dystrophy kinase binding protein (MKBP). It is expressed in the skeletal muscles and heart. Studies have also shown that HSPB2 is overexpressed in lung fibrosis. The gene encoding it is localized on human chromosome 11q22-q23. The gene ID of the protein is 3316.
特异性
Detects ~27 kDa.
免疫原
Synthetic peptide
生化/生理作用
Heat shock protein family B, member 2 (HSPB2) binds to ubiquitin and hydrogen peroxide-inducible clone 5, an adaptor protein. This association is important for the ubiquitination and degradation of NADPH oxidase 4 (Nox4). It is also crucial for the degradation of other proteins. HSPB2 interacts with myotonic dystrophy protein kinase (DMPK) and activates it.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
PBS, 50% glycerol, and 0.02% sodium azide
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Leena P Desai et al.
The Journal of biological chemistry, 289(26), 18270-18278 (2014-05-17)
Hydrogen peroxide-inducible clone 5 (Hic-5) is a focal adhesion adaptor protein induced by the profibrotic cytokine TGF-β1. We have demonstrated previously that TGF-β1 induces myofibroblast differentiation and lung fibrosis by activation of the reactive oxygen species-generating enzyme NADPH oxidase 4
Sankaralingam Prabhu et al.
PloS one, 7(1), e29810-e29810 (2012-01-25)
The small heat shock protein, human HspB2, also known as Myotonic Dystrophy Kinase Binding Protein (MKBP), specifically associates with and activates Myotonic Dystrophy Protein Kinase (DMPK), a serine/threonine protein kinase that plays an important role in maintaining muscle structure and
Xiaofei Chang et al.
International journal of oncology, 38(4), 1129-1135 (2011-01-25)
Hypermethylation of gene promoters and the corresponding loss of gene expression are recognized as a hallmark of human cancer, and DNA methylation has emerged as a promising biomarker for the detection of human esophageal squamous cell carcinoma (ESCC). To identify
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