生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
S73-20, monoclonal
形式
buffered aqueous glycerol solution
分子量
antigen predicted mol wt 120 kDa
种属反应性
mouse, rat, human
浓度
1 mg/mL
技术
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CNTN1(1272)
一般描述
Contactin-1 (CNTN1) is a neural cell adhesion molecule which is part of the immunoglobulin gene family. It is highly expressed in gastric cancers and the gene encoding it is localized on human chromosome 12q11–q12.
特异性
Deteects ~120 kDa.
免疫原
Synthetic peptide amino acids 21-37 (D/EFTWHRRYGHGVSEEDKC) extracellular domain of rat contactin, Accession Number A57112.
生化/生理作用
Contactin-1 (CNTN1) functions in the development of the nervous system and aids in tumor growth. It takes part in different biochemical pathways and interacts with many proteins like receptor protein tyrosine phosphatase-β (RPTP-β). In the nervous system, it also regulates interactions between proteins on the cell surface .
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Ruijie Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 71, 172-184 (2015-05-12)
Contactin-1 (CNTN-1), a glycosyl phosphatidylinositol anchor neural cell adhesion molecule (ACAM), is thought to function not only in nervous system development but also in the invasion and metastasis of several tumours. To investigate whether CNTN-1 is involved in multidrug resistance
De-Hu Chen et al.
Journal of cancer research and clinical oncology, 141(12), 2109-2120 (2015-05-09)
Contactin-1 (CNTN-1) has been shown to promote cancer metastasis. Previously, we have reported that the expression of CNTN-1 was upregulated in gastric cancer tissues compared with adjacent normal tissues. Here, we investigated the significance of CNTN-1 expression and its underlying
Mayur Dembla et al.
EMBO molecular medicine, 10(11) (2018-09-30)
Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto-immune response directed against myelin sheaths of the optic nerve. Here, we demonstrate in two frequently used
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