产品名称
单克隆抗-HCN4 小鼠抗, clone S114-10, 1 mg/mL, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S114-10, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 130 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... HCN4(59266)
Biochem/physiol Actions
检测~130 kDa。 与其他HCN无交叉反应
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
超极化激活的环核苷酸门控钾通道4（HCN4）是超极化激活的环核苷酸门控通道的亚基之一，在突触传递、树突整合、膜和动作电位中起作用。它是一个异源通道。HCN4在大鼠胚胎心脏中高度表达，特别是在窦房结中。
Immunogen
大鼠HCN4融合蛋白氨基酸1019-1198（C-末端），登录号Q9JKA7
Physical form
溶于PBS（pH 7.4）、50％甘油和0.09％叠氮化钠的溶液
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jingyun Dong et al.
Pacing and clinical electrophysiology : PACE, 42(2), 275-282 (2018-12-24)
The HCN4 gene encodes a subunit of the hyperpolarization-activated cyclic nucleotide-gated channel, type 4 that is essential for the proper generation of pacemaker potentials in the sinoatrial node. The HCN4 gene is often present in targeted genetic testing panels for
Valentina Prando et al.
The Journal of physiology, 596(11), 2055-2075 (2018-03-11)
The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a quasi-synaptic fashion. This is a result of
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
Milanesi R
The New England Journal of Medicine (2006)
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Zhang Q
Biochimica et Biophysica Acta (2009)
HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Hughes DI
Neuroscience (2013)
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