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生物来源
mouse
质量水平
偶联物
phycoerythrin (R-PE) conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
MEM-12, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
flow cytometry: suitable
同位素/亚型
IgG1
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... HLA-DRA(3122)
一般描述
Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6. HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.
The antibody MEM-12 recognizes common epitope on human HLA-DR which is dependent on the association of alpha and beta chains. DR is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
免疫原
Thymocyte membrane
应用
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
生化/生理作用
Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen. Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis.
Stokkers PC
Gut, 45, 395-401 (1999)
Monocytic HLA DR antigens in schizophrenic patients.
Krause D
Neuroscience Research, 72, 87-93 (2012)
HLA-DR peptide occupancy can be regulated with a wide variety of small molecules.
Blazekovic F
Human Vaccines & Immunotherapeutics, 12, 593-598 (2016)
Reactive microglia in patients with senile dementia
of the Alzheimer type are positive for the
histoconlpatibility glycoprotein HLA-DR
of the Alzheimer type are positive for the
histoconlpatibility glycoprotein HLA-DR
McGeer PL
Neuroscience Letters, 79, 195-200 (1987)
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