SAB4700541
Anti-CD261, low endotoxin antibody, Mouse monoclonal
clone DR-4-02, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DR4, Anti-TNFRSF10A, Anti-TRAIL-R1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
DR-4-02, monoclonal
Application:
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
immunocytochemistry
immunoprecipitation (IP)
Species reactivity:
human
Citations:
2
Technique(s):
flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
Uniprot accession no.:
产品名称
Anti-CD261, low endotoxin antibody, Mouse monoclonal, clone DR-4-02, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
DR-4-02, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
impurities
≤1 EU/μg endotoxin (LAL test)
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNFRSF10A(8797)
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 3-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
Physical form
Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Manami Semba et al.
International journal of molecular sciences, 23(13) (2022-07-10)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytotoxic cytokine that induces cancer cell death by binding to TRAIL receptors. Because of its selective cytotoxicity toward cancer cells, TRAIL therapeutics, such as recombinant TRAIL and agonistic antibodies targeting TRAIL receptors
Shu Yang et al.
Oncology letters, 11(6), 4167-4176 (2016-06-18)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. However, the potential use of TRAIL in the treatment of cancer is limited by the inevitable emergence of drug resistance.
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