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安全信息

SAB4700448

Sigma-Aldrich

单克隆抗 MYC-FITC，（C 端） 小鼠抗

clone 9E10, purified immunoglobulin, buffered aqueous solution

别名:

抗-c-Myc, 抗细胞骨髓细胞瘤病癌基因

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选择尺寸

100 μG
CN¥4,686.71

CN¥4,686.71

国内现货，预计发货时间April 23, 2025详情

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100 μG
CN¥4,686.71

About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

CN¥4,686.71

国内现货，预计发货时间April 23, 2025详情

生物来源

mouse

质量水平

100

偶联物

FITC conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

9E10, monoclonal

表单

buffered aqueous solution

种属反应性

human, fusion proteins in all species

浓度

1 mg/mL

技术

flow cytometry: suitable

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F2047WH0004609M2C6594
Monoclonal Anti-MYC-FITC , (C-terminal) antibody produced in mouse clone 9E10, purified immunoglobulin, buffered aqueous solution

SAB4700448

Monoclonal Anti-MYC-FITC , (C-terminal) antibody produced in mouse

Monoclonal Anti-c-Myc−FITC antibody produced in mouse clone 9E10, purified immunoglobulin, buffered aqueous solution

F2047

Monoclonal Anti-c-Myc−FITC antibody produced in mouse

Monoclonal Anti-MYC antibody produced in mouse clone 1G7, purified immunoglobulin, buffered aqueous solution

WH0004609M2

Monoclonal Anti-MYC antibody produced in mouse

Monoclonal Anti-c-Myc−Cy3™ antibody produced in mouse clone 9E10, purified immunoglobulin, buffered aqueous solution

C6594

Monoclonal Anti-c-Myc−Cy3™ antibody produced in mouse

species reactivity

human, fusion proteins in all species

species reactivity

human

species reactivity

human

species reactivity

human

Gene Information

human ... MYC(4609)

Gene Information

human ... MYC(4609)

Gene Information

human ... MYC(4609)

Gene Information

human ... MYC(4609)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

9E10, monoclonal

clone

9E10, monoclonal

clone

1G7, monoclonal

clone

9E10, monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

一般描述

细胞骨髓细胞瘤病（c-myc）基因位于人类染色体8q24上，它最初是从禽类骨髓细胞瘤病毒中分离的v-myc基因的细胞同源物。c-myc是MYC基因家族的成员。 c-Myc基因可编码碱性螺旋- 环-螺旋/亮氨酸拉链（bHLH/LZ）转录因子，该转录因子可调节G1-S细胞周期转变。在人癌症组织中观察到c-myc的表达增加。

免疫原

对应于人c-Myc C末端区域的合成肽序列（AEEQKLISEEDLL）

应用

小鼠单克隆抗MYC-FITC（C末端）抗体可用于免疫荧光和流式细胞术。

生化/生理作用

细胞骨髓细胞瘤病（c-myc）癌基因在细胞增殖、分化、凋亡中起重要作用，并可作为基因表达的转录调节因子。 c-Myc 表达对于协助大多数细胞进入细胞周期的合成（S）期是必要且充分的。编码的蛋白质在癌症发展和进展过程中的血管生成起着至关重要的作用。c-Myc 与其结合伴侣 Max 相互作用，并激活促生长基因的转录，如细胞周期蛋白 D2、鸟氨酸脱羧酶和转录因子 E2F1，它也通过与 Max 和 Sp1 或 Miz1复合物中的转录起始元件（Inr）结合抑制多种转录因子的转录，尤其是 p21 和 p27。

特点和优势

完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。

外形

溶于磷酸盐缓冲盐水，pH 7.4，含有15 mM 叠氮化钠。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    545625
    544552
    534048
    528039
    527127

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    Andrea Longatti et al.
    Nanoscale, 10(29), 14230-14244 (2018-07-17)
    Exosomes are extracellular vesicles that mediate cell-to-cell communication by transferring biological cargo, such as DNA, RNA and proteins. Through genetic engineering of exosome-producing cells or manipulation of purified exosomes, it is possible to load exosomes with therapeutic molecules and target
    Tomoki Maeda et al.
    Journal of immunology (Baltimore, Md. : 1950), 201(1), 202-214 (2018-05-18)
    The lymphotoxin (LT)/LTβ receptor (LTβR) axis is crucial for the regulation of immune responses and development of lymphoid tissues in mammals. Despite the importance of this pathway, the existence and function of LT and LTβR remain obscure for nonmammalian species.
    Original Ligand for LTbetaR Is LIGHT: Insight into Evolution of the LT/LTbetaR System
    Maeda T, et al.
    Journal of Immunology, 201(1), 202-214 (2018)
    Wei Zhang et al.
    Cell research, 12(1), 9-18 (2002-04-11)
    MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been characterized: extracellular signal-regulated kinase (ERK), Jun kinase (JNK/SAPK) and p38 MAPK. The above effects are fulfilled
    Bailey B Banach et al.
    Cell reports, 37(1), 109771-109771 (2021-09-30)
    Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a public antibody response encoded by IGHV3-53/IGHV3-66 genes. Sequence
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