推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
HM47, monoclonal
表单
buffered aqueous solution
种属反应性
pig, human, mouse
浓度
1 mg/mL
技术
flow cytometry: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... CD79A(973)
相关类别
一般描述
Cluster of differentiation 79A (CD79A), also known as mb-1 gene, is encoded by the gene mapped to human chromosome 19q13.2-13.3. The encoded protein is characterized with a single extracellular immunoglobulin domain, a transmembrane domain and an intracytoplasmic signaling domain with an immunoreceptor tyrosine-based activation motif (ITAM).
The antibody HM47 interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
免疫原
Synthetic peptide corresponding to amino acids 208-222 of human CD79a
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Cluster of differentiation 79A (CD79A) functions as a highly lineage-specific marker of B lymphoid cells. It also plays a crucial role in the diagnosis of acute leukemia. Mutations in the gene might be a cause of agammaglobulinemia. CD79A acts as an potential biomarker for the detection of B lineage neoplasms.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Giovanna Boi et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 64(1), 18-31 (2015-10-22)
Drying of the tissue section, partial or total, during immunostaining negatively affects both the staining of tissue antigens and the ability to remove previously deposited antibody layers, particularly during sequential rounds of de-staining and re-staining for multiple antigens. The cause
[Prognostic effect of cytoplasmic CD79a expression in acute myeloid leukemia with t(8;21)].
Chung HJ
The Korean Journal of Laboratory Medicine, 27, 388-393 (2007)
CD79a: A Novel Marker for B-Cell Neoplasms in Routinely Processed
Tissue Samples
Mason DY
Blood, 86, 1453-1459 (1995)
Mutations in Ig? (CD79a) result in a complete block in B-cell development
Minegishi Y
The Journal of Clinical Investigation, 104, 1115-1121 (1999)
Structure, chromosomal localization, and methylation pattern of the human mb-1 gene.
Ha H
Journal of Immunology, 152, 5749-5757 (1994)
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