生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
MEM-102, monoclonal
形式
buffered aqueous solution
种属反应性
nonhuman primates, human
浓度
1 mg/mL
技术
flow cytometry: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... CD48(962)
相关类别
一般描述
Cluster of differentiation 48 (CD48) molecule, also known as BLAST1, is encoded by the gene mapped to human chromosome 1q23.3. CD48 is a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of immunoglobulin superfamily. The encoded protein is expressed on various hematopoietic cells.
The antibody MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells; it is negative on granulocytes, platelets and erythrocytes.
免疫原
Raji human Burkitt′s lymphoma cell line
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Cluster of differentiation 48 (CD48) acts as an adhesion and co-stimulatory molecule and stimulates various effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils. CD48 interacts with its ligand CD2 and other molecules and promotes rearrangement of signaling factors in lipid rafts, Lck-kinase activity and tyrosine phosphorylation.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Characterization of the Epstein-Barr Virus-Inducible Gene
Encoding the Human Leukocyte Adhesion and
Activation Antigen BLAST-1 (CD48)
Fisher RC and Thorley-Lawson DA
Molecular and Cellular Biology, 11, 1614-1623 (1991)
The genetic differences between gallbladder and bile duct cancer cell lines.
Saito S
Oncology Reports, 16, 949-956 (2006)
CD48: A co-stimulatory receptor of immunity.
Elishmereni M and Levi-Schaffer F
The International Journal of Biochemistry & Cell Biology, 43, 25-28 (2011)
Soichiro Saito et al.
Oncology reports, 16(5), 949-956 (2006-10-04)
Biliary tract cancers carry dismal prognoses. It is commonly understood that chromosomal aberrations in cancer cells have prognostic and therapeutic implications. However, in biliary tract cancers the genetic changes have not yet been sufficiently studied. The aim of this study
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