推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 95 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr807)
基因信息
human ... CD22(933)
一般描述
CD22 (cluster of differentiation 22) is a 140 kDa single-spanning membrane glycoprotein present on the surface of B cells. This gene belongs to the sialic acid-binding Ig-type lectin (Siglec) family. CD22 is mapped to human chromosome 19q13.
免疫原
The antiserum was produced against synthesized peptide derived from human BL-CAM around the phosphorylation site of Tyr807.
Immunogen Range: 776-825
Immunogen Range: 776-825
生化/生理作用
CD22 (cluster of differentiation 22) helps to maintain B-cell homeostasis. This molecule act as an inhibitory coreceptor of the BCR (B cell receptor). CD22 is considered as a response regulator to control several aspects of B cell functions. Deficiency in CD22 or its pathways may contribute to autoimmunity.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
High Resolution Crystal Structures of Siglec-7 INSIGHTS INTO LIGAND SPECIFICITY IN THE SIGLEC FAMILY.
Alphey MS, et al.
The Journal of Biological Chemistry, 278(5), 3372-3377 (2003)
Molecular basis of human CD22 function and therapeutic targeting.
Ere?o-Orbea J, et al.
Nature Communications, 8(1), 764-764 (2017)
Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model.
Bednar KJ, et al.
Journal of Immunology, 199(9), 3116-3128 (2017)
B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
Fujimoto M, et al.
Journal of Immunology, 176(2), 873-879 (2006)
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