SAB4504517
Anti-phospho-PKR (pThr446) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DYT33, Anti-EIF2AK1, Anti-LEUDEN, Anti-PKR, Anti-PPP1R83, Anti-PRKR
产品名称
Anti-phospho-PKR (pThr446) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 62 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr446)
Quality Level
Gene Information
human ... EIF2AK2(5610)
Biochem/physiol Actions
EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferons. This gene is involved in stress responses and inflammation pathways. This gene controls the development and multiplication of cells, nutrient signaling and metabolism. EIF2AK2 also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2αfamily of protein kinases. PKR contains two RNA binding domains and a kinase domain. This gene is located on human chromosome 2p22-p21.
Immunogen
The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446.
Immunogen Range: 413-462
Immunogen Range: 413-462
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Regulation of PKR by RNA: formation of active and inactive dimers
Husain B, et al.
Biochemistry, 54(44), 6663-6672 (2015)
Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease
Varghese GP, et al.
Molecular Medicine Reports, 11(6), 4579-4584 (2015)
Yimeng Gao et al.
Immunity, 52(6), 1007-1021 (2020-06-05)
N6-methyladenosine (m6A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m6A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal
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