推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 43 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer368)
基因信息
human ... GJA1(2697)
一般描述
Connexin 43 (Cx43) is also known as GJA1 (gap junction protein alpha 1) and belongs to a large family of homologous connexin proteins. This protein has an intracellular N-terminus, four transmembrane domains, two extracellular loops, one cytoplasmic loop and an intracellular C-terminus. It is located on human chromosome 6q22-q23.
免疫原
The antiserum was produced against synthesized peptide derived from human Connexin 43 around the phosphorylation site of Ser368.
Immunogen Range: 332-381
Immunogen Range: 332-381
生化/生理作用
Connexin 43 participates in the multiplication and differentiation of mature T cells. This protein also participates in the secretion and manufacturing of cytokines. Mutations in connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. CX43 helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.
Ni X, et al.
PLoS ONE, 12(9), e0184773-e0184773 (2017)
Jie Yu et al.
Molecular human reproduction, 25(10), 625-637 (2019-08-14)
Human blastocyst nidation in the uterus and successful pregnancy require coordinated endometrial expression of estrogen receptor (ER)-α, progesterone receptors (PR)-A and -B and the gap junction protein, connexin (Cx)43. Our prior work established that inflammation associated with conditions of reduced
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells.
Dovmark T H, et al.
Oncogene, 36(32), 4538-4538 (2017)
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia.
Paznekas W A, et al.
American Journal of Human Genetics, 72(2), 408-418 (2003)
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