生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 31 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer150)
基因信息
human ... CASP3(836)
一般描述
Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3 is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3 is mapped to human chromosome 4q35.1.
免疫原
The antiserum was produced against synthesized peptide derived from human Caspase 3 around the phosphorylation site of Ser150.
Immunogen Range: 116-165
Immunogen Range: 116-165
生化/生理作用
Caspase-3 (CASP3) can degenerate multiple cellular proteins and results in morphological changes and DNA fragmentation in cells at the time of apoptosis. It participates in the growth stimulation. CASP3 plays a major role in the execution phase of apoptosis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children.
Kuo HC, et al.
Journal of Human Genetics, 56(2), 161?165-161?165 (2011)
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
Liu PF, et al.
PLoS ONE, 12(7), e0180620-e0180620 (2017)
Caspase 3?mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Huang Q, et al.
Nature Medicine, 17(7), 860?866-860?866 (2011)
Identification of SMURF1 as a possible target for 7q21. 3?22.1 amplification detected in a pancreatic cancer cell line by in?house array?based comparative genomic hybridization.
Suzuki A, et al.
Cancer Science, 99(5), 986-994 (2008)
Guojun Yang et al.
Nanotheranostics, 7(4), 380-392 (2023-07-10)
Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as
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