产品名称
抗 磷酸-肌球蛋白调节轻链 2 (pSer 18 ) 兔抗, affinity isolated antibody
clone
polyclonal
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
form
buffered aqueous solution
mol wt
antigen 19 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer18)
Quality Level
Gene Information
human ... MYL2(4633)
Biochem/physiol Actions
MYL2 (myosin light chain 2) helps to convert energy from ATP hydrolysis into mechanical force. This gene also plays a major role in the growth and progression of chronic HF (heart failure). Mutation in MYL2 gene result in infantile type I muscle fibre disease and cardiomyopathy.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
MYL2 (myosin light chain 2) encodes a myosin regulatory light chain (MLC-2V). It is made of two heavy chains, two essential light chains and two regulatory light chains. It is located on human chromosome 12q24.
Immunogen
The antiserum was produced against synthesized peptide derived from human Myosin regulatory light chain 2 around the phosphorylation site of Ser18.
Immunogen Range: 3-52
Immunogen Range: 3-52
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic heart failure patients
Li Y, et al.
Clinical Cardiology, 34(1), 30-34 (2011)
Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2,DCN, EPS8, andRPL6
ION A, et al.
Journal of medical Genetics, 37(11), 884-886 (2000)
Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy
Weterman MA, et al.
Brain (2013)
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