生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 68 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pThr210)
基因信息
human ... PLK1(5347)
一般描述
Human polo-like kinase 1 (PLK1) is a serine/threonine kinase, that is located on human chromosome 16p12.
免疫原
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Thr210.
Immunogen Range: 176-225
Immunogen Range: 176-225
生化/生理作用
Polo-like kinase 1 (PLK1) plays an important role in the functional maturation of mitotic centrosomes. It actively participates in the development of the cell cycle. This gene is considered as an important therapeutic target as it is overexpressed in several cancer types.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1
Petronczki M, et al.
Developmental Cell, 14(5), 646-659 (2008)
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
Kolberg M, et al.
Molecular Oncology, 11(9), 1156-1171 (2017)
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
H A Lane and E A Nigg
The Journal of Cell Biology, 1701-1713 (1996)
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