一般描述
Phospholamban (PLN) gene codes for a small integral membrane protein. It is located on human chromosome 6q22.1. PLN is a 52-amino-acid phosphoprotein.
免疫原
The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17.
Immunogen Range: 1-50
Immunogen Range: 1-50
生化/生理作用
Phospholamban (PLN) participates in calcium signalling and muscle contraction. This protein regulates the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) of cardiac myocytes. Mutations in the phospholamban (PLN) gene result in dilated cardiomyopathy (DCM) and severe heart failure.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
Haghighi K, et al.
The Journal of Clinical Investigation, 111(6), 869-876 (2003)
Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
Smeazzetto S, et al.
Physical Chemistry Chemical Physics, 18(3), 1629-1636 (2016)
Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy.
Bos J M, et al.
Journal of the American College of Cardiology, 54(3), 201-211 (2009)
Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.
Fish M, et al.
Scientific Reports, 6, 22235-22235 (2016)
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