推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 47 kDa
种属反应性
rat, human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer412)
基因信息
human ... ARRB1(408)
一般描述
Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13.
免疫原
The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412.
Immunogen Range: 369-418
Immunogen Range: 369-418
生化/生理作用
Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response
Shen H, et al.
Oncology Reports, 37(2), 761-767 (2017)
?-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor
Qiu C, et al.
International Journal of Clinical and Experimental Pathology, 8(4), 3785-3793 (2015)
ARRB1/?-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
Wang P, et al.
Autophagy, 10(9), 1535-1548 (2014)
Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13
Calabrese G, et al.
Genomics, 24(1), 169-171 (1994)
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