生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 116 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer855/pSer554)
基因信息
human ... LIPE(3991)
一般描述
Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. The gene coding for a protein is mapped on human chromosome 19q13. The encoded protein is an intracellular lipase with various neutral lipid substrates, such as triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. HSL is widely expressed.
免疫原
The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser855/554.
Immunogen Range: 520-569
Immunogen Range: 520-569
生化/生理作用
Hormone sensitive lipase (HSL) plays an important role in various processes such as lipolysis, adipocytes, steroidogenesis and spermatogenesis. Deficiency of HSL contributes to histologic abnormalities in white adipose tissue and an increase in macrophage infiltration. Polymorphism in the gene has been observed in familial lipodystrophies patients.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy.
Farhan SM, et al.
The Canadian Journal of Cardiology, 30, 1649-1654 (2014)
Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes
Albert JS, et al.
The New England Journal of Medicine, 370, 2307-2315 (2014)
Identification of Microdeletions Spanning the Diamond-Blackfan Anemia Locus on 19q13 and Evidence for Genetic Heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63, 1388-1395 (1998)
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