生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 52 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer465)
基因信息
human ... SMAD1(4086)
一般描述
Smad1 (SMAD family member 1) is a transcriptional activator, that is located on human chromosome 4q31.
免疫原
The antiserum was produced against synthesized peptide derived from human Smad1 around the phosphorylation site of Ser465.
Immunogen Range: 416-465
Immunogen Range: 416-465
生化/生理作用
SMAD (homologues of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma) proteins have a major role in disease development and hence act as biologic prognostic factors in diseases. miR-345 represses the multiplication, invasion and migration of prostate cancer by downregulating Smad1.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(3), 1010428317694551-1010428317694551 (2017)
MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer
Journal of Cancer Research and Clinical Oncology, 142(1), 213-224 (2016)
An interstitial 4q31.21q31.22 microdeletion associated with developmental delay: case report and literature review
Cytogenetic and genome research, 142(4), 227-238 (2014)
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
Cell, 131(5), 980-993 (2007)
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