biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 97 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDH1(999)
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General description
CDH1(钙粘蛋白 1)编码位于人类染色体 16q22.1 的跨膜糖蛋白 E-钙粘蛋白。它是一种肿瘤抑制基因,也被称为 Cdh1p/Hct1p、fizz-related、Ste9 或 Srw1。
抗 E-钙粘蛋白抗体检测内源性总 E-钙粘蛋白水平。
Immunogen
抗血清是针对合成的人 E-钙粘蛋白肽。
免疫原范围:1-50
免疫原范围:1-50
Application
抗 E-钙粘蛋白、N-末端抗体可用于蛋白提取、蛋白质印迹、共聚焦荧光显微镜分析、免疫染色和免疫共沉淀。
Biochem/physiol Actions
CDH1(钙粘蛋白 1)有助于保存上皮组织中嗜同性细胞间粘附(homophilic cell-cell adhesion)。CDH1 表达不足导致结肠癌 和肾细胞癌 (RCC)。
Features and Benefits
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Physical form
兔 IgG 溶于磷酸盐缓冲盐水(不含 Mg2+ 和 Ca2+),pH7.4,150mM NaCl,0.02% 叠氮化钠和 50% 甘油中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer
Itou J, et al.
Febs Letters, 587(18), 3115-3121 (2013)
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer
Caldeira JR, et al.
BMC Cancer (2006)
Junji Itou et al.
FEBS letters, 587(18), 3115-3121 (2013-08-21)
In cell cultures, the dispersed phenotype is indicative of the migratory ability. Here we characterized Sal-like 4 (SALL4) as a dispersion factor in basal-like breast cancer. Our shRNA-mediated SALL4 knockdown system and SALL4 overexpression system revealed that SALL4 suppresses the
MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1? in Gallbladder Cancer
He M, et al.
Cellular Physiology and Biochemistry, 42(5), 2078-2092 (2017)
Electric field exposure promotes epithelial?mesenchymal transition in human lens epithelial cells via integrin ?1?FAK signaling
Liu J, et al.
Molecular Medicine Reports, 16(4), 4008-4014 (2017)
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