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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 133 kDa
种属反应性
mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CP135(9662)
一般描述
Anti-CEP135 Antibody detects endogenous levels of total CEP135 protein.
Cep135 (centrosomal protein 135) is a cartwheel protein. It has a coiled-coil domain and conserved regions near the N-terminus and the C-terminus, respectively. It is mapped to human chromosome 4q12.
免疫原
The antiserum was produced against synthesized peptide derived from human CEP135.
Immunogen Range: 1081-1130
Immunogen Range: 1081-1130
应用
Anti-CEP135, C-Terminal antibody has been used in immunofluorescence staining.
生化/生理作用
Mutation in Cep135 (centrosomal protein 135) result in primary microcephaly. It induces centriole assembly and stability. CEP135 helps to maintain the structure and organization of microtubules. This protein plays a major role in centriole biogenesis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function
Hussain MS, et al.
American Journal of Human Genetics, 90(5), 871-878 (2012)
A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family
Farooq M, et al.
Journal of Human Genetics, 61(3), 271-273 (2016)
Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7
Noordstra I, et al.
Journal of Cell Science, 129(22), 4278-4288 (2016)
A Short CEP135 Splice Isoform Controls Centriole Duplication
Dahl KD, et al.
Current Biology, 25(19), 2591-2596 (2015)
Peter Jan Hooikaas et al.
eLife, 9 (2020-12-22)
When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known about how the regulation of microtubule
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