推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 120 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CASR(846)
一般描述
Anti-Calcium Sensing Receptor Antibody detects endogenous levels of total Calcium Sensing Receptor protein.
The calcium sensing receptor (CASR) is a 1078 amino acid protein. It has 11 exons and is located on human chromosome 3q13.33-q21.1. CASR belongs to the C family of G protein–coupled receptors. It is located in the parathyroid gland and the thick ascending limb of the Henle loop.
免疫原
The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor.
Immunogen Range: 854-903
Immunogen Range: 854-903
生化/生理作用
Calcium sensing receptor (CASR) modulates the activities of cells according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. CASR has a vital role in signal transduction pathways in various tissues like parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is linked with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis
Taguchi K, et al.
European eurology focus, 3(1), 72-81 (2017)
Calcium-Sensing Receptors
Goodman WG.
Seminars in Nephrology, 24 (2004)
Guoliang Zhang et al.
Aging, 11(19), 8313-8328 (2019-10-03)
In this study, we used high-throughput RNA sequencing to identify mRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are differentially expressed in the Substantia Nigra (SN) of aged and young rats. Gene Ontology and Kyoto Encyclopedia of Genes
Elena Dyukova et al.
Journal of cellular physiology, 232(9), 2508-2518 (2016-09-24)
Nitric oxide (NO)-deficiency as it occurs during endothelial dysfunction activates the endothelin-1 (ET-1) system and increases the expression of receptor activity modifying protein (RAMP)-1 that acts as a chaperon for calcium-sensing receptors (CaR) that have recently been identified to improve
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