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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 39 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TUSC3(7991)
一般描述
Tumor suppressor candidate 3 (TUSC3) codes for a subunit of the endoplasmic reticulum-bound oligosaccharyltransferase complex. It is a 348 amino acid protein, that has 11 exons spanning ∼224 Kbp of the genomic DNA. TUSC3 has five potential transmembrane domains and is located on human chromosome 8p22.
免疫原
The antiserum was produced against synthesized peptide derived from human TUSC3.
Immunogen Range: 131-180
Immunogen Range: 131-180
应用
Anti-TUSC3 antibody has been used in immunohistochemistry, immunoblotting and co-immunoprecipitation.
生化/生理作用
Tumor suppressor candidate 3 (TUSC3) is a tumor suppressor gene, that is responsible for autosomal recessive mental retardation. It participates in catalyzing the transfer of a 14-sugar oligosaccharide from dolichol to nascent protein. Absence of TUSC3 is associated with lymph node metastasis in larynx and pharynx squamous cell carcinomas.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Oncogenic function of TUSC3 in non-small cell lung cancer is associated with Hedgehog signalling pathway
Gu Y, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(7), 1749-1760 (2017)
A defect in the TUSC3 gene is associated with autosomal recessive mental retardation
Garshasbi M, et al.
American Journal of Human Genetics, 82(5), 1158-1164 (2008)
Shoujie Wang et al.
Cell biochemistry and function, 38(5), 604-612 (2020-02-25)
Melanoma is a highly malignant and is a life-threatening disease with no effective treatment currently. This study aims to evaluate the significance of TUSC3, an endoplasmic reticulum stress (ERS)-inducible gene and explore its relationship with AKT/GSK3-β/β-catenin signalling pathway in melanoma
Ahmed Magzoub Khalid et al.
Bioscience, biotechnology, and biochemistry, 77(10), 2019-2024 (2013-10-08)
Analysis of microarray data obtained by comparing gene expression between 2-week-old infant and 7-week-old mature SD rat testes revealed novel targets involved in tumor suppression. Reverse-transcription polymerase chain reaction and Northern blotting indicated that Tusc3 gene expression was upregulated in
David L Lin et al.
mBio, 8(4) (2017-07-20)
Dengue virus (DENV) is the most common arboviral infection globally, infecting an estimated 390 million people each year. We employed a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen to identify host dependency factors required for DENV propagation and
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