生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 47 kDa
antigen 76 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
proteolytically cleaved (Arg437)
基因信息
human ... C1S(716)
一般描述
Anti-C1S (heavy chain, Cleaved-Arg437 Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg437protein.
The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.
免疫原
The antiserum was produced against synthesized peptide derived from human C1S.
Immunogen Range: 388-437
Immunogen Range: 388-437
生化/生理作用
Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
Perry AJ
The Journal of Biological Chemistry, 288(22), 15821?15829-15821?15829 (2013)
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.
Duncan RC
Journal of Immunology, 189(5), 2365-2373 (2012)
Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice
Tamura K
Nephron: Experimental Nephrology, 123(3-4), 34-45 (2013)
Elucidation of the substrate specificity of the C1s protease of the classical complement pathway.
Kerr FK
The Journal of Biological Chemistry, 280(47), 39510-39514 (2005)
Complement genetics, deficiencies, and disease associations
Mayilyan KR
Protein & cell, 3(7), 487?496-487?496 (2012)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门