推荐产品
产品名称
Anti-Tyrosine Hydroxylase, N-Terminal antibody produced in rabbit, affinity isolated antibody
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 58 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TH(7054)
一般描述
Anti-Tyrosine Hydroxylase Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
The TH (tyrosine Hydroxylase) gene codes for a homotetramer that contains catalytic, regulatory, and tetramerization domains in each of its subunits.
免疫原
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase.
Immunogen Range: 10-59
Immunogen Range: 10-59
生化/生理作用
The conversion of l-tyrosine into l-DOPA is catalyzed by tyrosine hydroxylase (TH), which is the rate-limiting step in the in the synthesis of catecholamines such as dopamine and also other necessary hormones and neuromodulators. TH enzyme deficiency results in low levels of dopamine, which is characterised in Parkinson′s disease.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.
Jorge-Finnigan A
The Journal of Biological Chemistry, 292(34), 14092-14107 (2017)
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.
Ghorbani S
Amino Acids, 48(5), 1221-1229 (2016)
Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.
Kumar AS
The Journal of Biological Chemistry, 291(23), 12310-12321 (2016)
Izel Tekin et al.
Parkinsonism & related disorders, 23, 86-90 (2016-01-07)
Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. We investigated whether the presence of a common TH polymorphism
Wenyan Zou et al.
Translational neurodegeneration, 8, 7-7 (2019-03-15)
Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies have revealed an essential role of glymphatic
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