生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 55 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TGFBR1(7046)
一般描述
抗-TGF β受体I抗体可检测内源性总TGF β受体I蛋白水平。
转化生长因子β受体-1 (TGF-β R1)，也称为激活素受体样激酶5(ALK5)受体，由人类染色体9q22.3上的基因编码。在人类组织中广泛表达。
免疫原
该抗血清是靶向人TGFβ受体I合成肽制备的。
免疫原范围：131-180
免疫原范围：131-180
应用
兔抗-TGF-β受体I抗体已用于免疫组化。
- 免疫组织化学
- 蛋白质印迹
- 免疫荧光
生化/生理作用
转化生长因子β 受体-1 （TGF-β R1）增进肺成纤维细胞中胶原蛋白的生成，在碳纳米管诱导的纤维发生中起着至关重要的作用。 TβR依赖性信号在细胞生长和分化中起关键作用，TGF-β R1 的多态性或突变导致头颈癌。 激活素受体样激酶5（ALK5）或 TGF-β R1 促进Smad 2 (small mothers against decapentaplegic) 和Smad3 的磷酸化。活化的ALK5 抑制内皮细胞（EC）的迁移和增殖。ALK1可用作ALK5/Smad信号传导的拮抗剂。TGF-βR1 的突变也可导致名为多发性自愈性鳞状上皮瘤（MSSE）或Ferguson-Smith 病（FSD）的常染色体显性皮肤癌。
特点和优势
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您全额赔偿或更换抗体。了解更多。
外形
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4，150mM NaCl，0.02％叠氮化钠和50％甘油中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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