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产品名称
Anti-Synuclein-α antibody produced in rabbit, affinity isolated antibody
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 14 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SNCA(6622)
一般描述
Anti-Synuclein-α antibody detects endogenous levels of total Synuclein-α protein.
The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1.
免疫原
The antiserum was produced against synthesized peptide derived from human Synuclein-alpha.
Immunogen Range: 86-135
Immunogen Range: 86-135
生化/生理作用
Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Jian-Feng Li et al.
Foods (Basel, Switzerland), 13(9) (2024-05-11)
Parkinson's disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a
SNCA variants are associated with increased risk for multiple system atrophy.
Scholz SW
Annals of Neurology, 65(5), 610-614 (2009)
Synucleins Have Multiple Effects on Presynaptic Architecture.
Vargas KJ
Cell Reports, 18(1), 161-173 (2017)
?-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.
Ettle B
Acta Neuropathologica, 132(1), 59-75 (2016)
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