生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 33 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SFRP2(6423)
一般描述
Anti-SFRP2 Antibody detects endogenous levels of total SFRP2 protein.
The SFRP2 (secreted frizzled related protein 2) gene is mapped to human chromosome 4q31.3. It is found to be expressed in sclerotome.
免疫原
The antiserum was produced against synthesized peptide derived from human SFRP2.
Immunogen Range: 119-168
Immunogen Range: 119-168
生化/生理作用
SFRP2 (secreted frizzled related protein 2) promotes phosphorylation and retards the expression of nuclear β-catenin and inhibits the canonical Wnt signaling pathway. SFRP2 is known to enhance osteogenic differentiation in mesenchymal stem cells.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
Lee CS
Development, 127(1), 109-118 (2000)
A novel susceptibility locus for Hirschsprung's disease maps to 4q31.3-q32.3.
Brooks AS
Journal of medical Genetics, 43(7), 1-6 (2006)
SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway.
Jin L
Cellular & Molecular Biology Letters, 22:14, 1-14 (2017)
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