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安全信息

SAB4502721

Sigma-Aldrich

Anti-Syndecan4 antibody produced in rabbit

affinity isolated antibody

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别名:
Amphiglycan, Ryudocan core protein, SDC4, SYND4, Syndecan-4 precursor
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen 21 kDa

种属反应性

rat, human, mouse

浓度

~1 mg/mL

技术

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SDC4(6385)

一般描述

The SDC-4 (syndecan-4) gene encodes a membrane-spanning proteoglycan which can bear heparan sulfate and chondroitin sulfate chains. Syndecan-4 is predominantly expressed on smooth muscle cells, epithelial cells and cardiomyocytes. The SDC-4 gene is mapped to human chromosome 20q13.12. Anti-Syndecan4 antibody detects endogenous levels of total syndecan-4 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human Syndecan4.

Immunogen Range: 145-194

生化/生理作用

Syndecan-4 (SDC-4) is associated with bone development and osteogenesis by regulating fibroblast growth factor-2 (FGF2). SDC-4 gene expression promotes cell division, migration and adhesion. It is essential for wound healing and takes part in inflammation and fibrosis. An abnormal SDC-4 expression is observed in response to stress and metastatic tumor. Growth factors such as FGF2, TNF-α (tumor necrosis factor α) and TGF-β (transforming growth factor β) also tend to alter SDC-4 expression. It is implicated as a biomarker in cardiovascular disease.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCalpha signalling and cross-talk with TGFbeta
Borland SJ, et al.
Cardiovascular Research, 113(13), 1639-1652 (2017)
Killing two birds with one stone: Dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification
Qin Y, et al.
Cell Death & Disease, 8(7), e2920-e2920 (2017)
Chromosome 22q13. 3 deletion syndrome with a de novo interstitial 22q13. 3 cryptic deletion disrupting SHANK3
Delahaye A, et al.
European Journal of Medical Genetics, 52(5), 328-332 (2009)
Lack of association between serum syndecan-4, myocardial fibrosis and ventricular dysfunction in subjects with chronic Chagas disease
Larocca TF, et al.
PLoS ONE, 12(12), e0189408-e0189408 (2017)

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