产品名称
抗-CD45 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 147 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTPRC(5788)
Application
兔抗CD45抗体可用于：
- 免疫组织化学染色
- 免疫荧光染色
- 免疫染色
Biochem/physiol Actions
CD45 编码的蛋白（分化抗原簇 45）是一个原型受体，具有磷酸酶活性。研究发现 CD45 控制 T 细胞介导的 BCR 信号传导。
分化簇45 (CD45)促进淋巴细胞信号传导和SRC家族激酶Lck的调控。这种蛋白质参与了几种哺乳动物的多态性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
CD45（分化簇45）基因定位于人类染色体1q31.3-q32.1。它编码一型跨膜蛋白，并和其前体一起在成核的造血细胞中表达。该蛋白由多个胞外结构域和一个高度保守的胞内结构域组成。
抗-CD45 抗体检测内源性总 CD45 蛋白水平。
Immunogen
针对人源 CD45 的合成肽产生抗血清。
免疫原范围：981-1030
免疫原范围：981-1030
Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH 7.4，含150mM NaCl、0.02％叠氮化钠和50％甘油。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Milja Arponen et al.
Frontiers in physiology, 13, 1035516-1035516 (2022-12-17)
Bone is an active tissue that undergoes constant remodeling. Bone formation requires energy and one of the energy sources of bone-forming osteoblasts is glucose, which is transported inside the cells via glucose transporters. However, the role of class I glucose
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A
European Journal of Immunology, 47(1), 193-205 (2017)
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.
Szodoray P
The Journal of Allergy and Clinical Immunology, 138(3), 839-851 (2016)
Sathish Babu Vasamsetti et al.
Immunity, 49(1), 93-106 (2018-07-01)
There is a growing body of research on the neural control of immunity and inflammation. However, it is not known whether the nervous system can regulate the production of inflammatory myeloid cells from hematopoietic progenitor cells in disease conditions. Myeloid
Nick Holmes
Immunology, 117(2), 145-155 (2006-01-21)
CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the
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