推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 138 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KCNT1(57582)
一般描述
Anti-KCNT1 antibody detects endogenous levels of total KCNT1 protein.
The KCNT1 (potassium sodium-activated channel subfamily T member 1) gene is mapped to human chromosome 9q34.3. It is widely expressed in the brain, heart and dorsal root ganglia and well distributed in the nervous system.
免疫原
The antiserum was produced against synthesized peptide derived from human KCNT1.
Immunogen Range: 1019-1068
Immunogen Range: 1019-1068
生化/生理作用
Mutations in KCNT1 (potassium sodium-activated channel subfamily T member 1) is observed in different epileptic disorders including epileptic encephalopathy, nocturnal frontal lobe epilepsy and malignant migrating partial seizures in infancy. KCNT1 is associated with neural oscillation and general learning disability. It also controls pain sensation.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mutations in KCNT1 cause a spectrum of focal epilepsies.
M?ller RS
Epilepsia, 56(9) (2015)
Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.
Heron SE
Nature Genetics, 44(11), 1188-1190 (2012)
Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.
Tang QY
Cell Reports, 9314(1), 129-139 (2016)
Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.
Fleming MR
Cell Reports, 16(9), 2281-2288 (2016)
Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy.
Rizzo F
Molecular and Cellular Neurosciences, 72, 54-63 (2016)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门