推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 41 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CXCR7(57007)
一般描述
Anti-CXCR7 Antibody detects endogenous levels of total CXCR7 protein.
CXC- Chemokine receptor 7 (CXCR7) protein is a seven-transmembrane G-protein coupled receptor (GPCR). It is expressed in the heart tissues, fetal hematopoietic cells, embryonic neuronal, and activated endothelium. CXCR7 gene is mapped on the human chromosome at 2q37.3.
免疫原
The antiserum was produced against synthesized peptide derived from human CXCR7.
Immunogen Range: 311-360
Immunogen Range: 311-360
生化/生理作用
CXC- Chemokine receptor 7 (CXCR7) protein interacts with chemokine ligands CXCL11 and CXCL12. This protein shuffles between the plasma membrane and endosomal compartments irrespective of the presence of a ligand such as CXCL11 and 12. CXCR7 protein plays a role in cell survival and cell adhesion to the endothelium. This protein tends to regulate the activity of CXCR4.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Lorena Sánchez-Martín et al.
Trends in molecular medicine, 19(1), 12-22 (2012-11-17)
It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation
Angélique Levoye et al.
Blood, 113(24), 6085-6093 (2009-04-22)
The stromal cell-derived factor-1/CXCL12 chemokine engages the CXCR4 and CXCR7 receptors and regulates homeostatic and pathologic processes, including organogenesis, leukocyte homeostasis, and tumorigenesis. Both receptors are widely expressed in mammalian cells, but how they cooperate to respond to CXCL12 is
Ulrike Naumann et al.
PloS one, 5(2), e9175-e9175 (2010-02-18)
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest
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