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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 31 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TMEPA(56937)
一般描述
Anti-TMEPA Antibody detects endogenous levels of total TMEPA protein.
The transmembrane prostate androgen-induced RNA (TMEPAI), also known as prostate transmembrane protein androgen induced 1 (PMEPA1) gene, spans 55-60 kb on human chromosome 20q13.31-q13.33. The encoded protein is mainly expressed in prostate gland and is regulated by androgen receptor (AR). TMEPAI is a type Ib transmembrane protein characterized with two PY motifs involved in binding HECT(homologous to the E6AP carboxyl terminus)-type E3 ubiquitin ligases.
免疫原
The antiserum was produced against synthesized peptide derived from human TMEPA.
Immunogen Range: 101-150
Immunogen Range: 101-150
生化/生理作用
Transmembrane prostate androgen-induced RNA (TMEPAI)/ prostate transmembrane protein androgen induced 1 (PMEPA1) plays a vital role in maintaining prostate homeostasis. It is also implicated in p53-mediated apoptosis and cell growth inhibition.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Transmembrane prostate androgen-induced protein 1 (PMEPA1) promotes the migration and maintains mesenchymal-like phenotype of breast cancer cells
Zou Y, et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(2), 158-162 (2016)
TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling
Watanabe Y, et al.
Molecular Cell, 37(1), 123-134 (2010)
Wei Wu et al.
International journal of cancer, 143(9), 2213-2224 (2018-05-16)
TGF-β plays a central role in mediating epithelial-mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF-β-induced EMT is NF-κB-dependent in various cancer types. However, it is largely unclear if NF-κB mediates TGF-β-induced EMT in
Shashwat Sharad et al.
Epigenetics, 9(6), 918-927 (2014-04-04)
The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR). AR protein levels are controlled by the AR-PMEPA1 negative feedback loop through NEDD4-E3
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