SAB4502211
Anti-PLK1 antibody produced in rabbit
affinity isolated antibody
别名:
PLK-1, Polo-like kinase 1, STPK13, Serine/threonine-protein kinase 13
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Species reactivity:
human, mouse, rat
Citations:
4
Technique(s):
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
Anti-PLK1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 68 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLK1(5347)
Biochem/physiol Actions
PLK1 (polo like kinase 1) is predominantly involved in mitosis. It mediates the phosphorylation of cyclin B1/CDK1 (cyclin dependent kinase 1) complex, and activation of the anaphase promoting complex. PLK1 has anti-apoptotic function. Upregulation of gene is observed in different types of cancer, such as colorectal cancer and is regarded as an oncogene. PLK1 is involved in checkpoint recovery and adaptation following DNA damage.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-PLK1 Antibody detects endogenous levels of total PLK1 protein.
PLK1 (polo like kinase 1) gene is mapped to human chromosome 16p12.2. It codes for the protein serine/threonine kinase.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1.
Immunogen Range: 176-225
Immunogen Range: 176-225
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma.
Amani V
BMC Cancer, 16:647, 1-9 (2016)
PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.
Koncar RF
Oncotarget, 8(9), 15827-15837 (2017)
Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
Rouquier S
Disease Markers, 2014:798170, 1-6 (2014)
Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein ? to mediate colon carcinoma cell differentiation and apoptosis.
Dasgupta N
Biochimica et Biophysica Acta, 1861(7), 1777-1787 (2017)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持